Molecular characterization of mutations in thehprt gene of normal human skin keratinocytes treated withN-ethyl-N-nitrosourea: Influence of O6-alkylguanine alkyltransferase

1997 ◽  
Vol 29 (2) ◽  
pp. 168-179 ◽  
Author(s):  
Hua Hua Tong ◽  
Jeong Hae Park ◽  
Tonya Brady ◽  
Christopher M. Weghorst ◽  
Steven M. D`Ambrosio
Keyword(s):  
Molecular Characterization ◽  
Human Skin ◽  
Normal Human Skin ◽  
Skin Keratinocytes ◽  
Normal Human

Organophosphorus flame retardant TDCPP-induced cytotoxicity and associated mechanisms in normal human skin keratinocytes

2020 ◽  
Vol 726 ◽  
pp. 138526 ◽  
Author(s):  
Daolei Cui ◽  
Jue Bi ◽  
Zhen-Ning Zhang ◽  
Meng-Ying Li ◽  
Yi-Shu Qin ◽  
...  
Keyword(s):  
Flame Retardant ◽  
Human Skin ◽  
Normal Human Skin ◽  
Skin Keratinocytes ◽  
Normal Human

scholarly journals Immunoelectron Microscopic Characterization of Human Dermal Lymphatic Microvascular Endothelial Cells: Differential Expression of CD31, CD34, and Type IV Collagen with Lymphatic Endothelial Cells vs Blood Capillary Endothelial Cells in Normal Human Skin, Lymphangioma, and Hemangioma In Situ

1998 ◽  
Vol 46 (2) ◽  
pp. 165-176 ◽  
Author(s):  
Birthe Sauter ◽  
Dagmar Foedinger ◽  
Barbara Sterniczky ◽  
Klaus Wolff ◽  
Klemens Rappersberger
Keyword(s):  
Endothelial Cells ◽  
Human Skin ◽  
Type Iv Collagen ◽  
Microvascular Endothelial Cells ◽  
Lymphatic Endothelial Cells ◽  
Normal Human Skin ◽  
Type Iv ◽  
Normal Human ◽  
Microvascular Endothelial

We performed a comparative investigation of the immunomorphological characteristics of lymphatic and blood microvascular endothelial cells in normal human skin, cutaneous lymphangiomas, and hemangiomas, employing a pre-embedding immunogold electron microscopic technique. We stained for cell membrane proteins that are commonly used for light microscopic characterization of blood endothelial cells. With blood microvascular endothelial cells, we observed uniform labeling of the luminal cell membranes with monoclonal antibodies (MAbs) JC70 (CD31), EN-4 (CD31), BMA120, PAL-E, and QBEND-10 (CD34), and strong staining of the vascular basal lamina for Type IV collagen under normal and pathological conditions. In contrast, lymphatic microvascular endothelial cells in normal human skin and in lymphangiomas displayed, in addition to a luminal labeling, pronounced expression of CD31 and CD34 along the abluminal cell membranes. Moreover, CD31 was preferentially detected within intercellular junctions. The expression of CD34 was mostly confined to abluminal endothelial microprocesses and was upregulated in lymphangiomas and hemangiomas. Type IV collagen partially formed the luminal lining of initial lymphatics and occasionally formed bridges over interendothelial gaps. Our findings suggest a function of transmigration protein CD31 in recruitment of dendritic cells into the lymphatic vasculature. CD34 labeling may indicate early endothelial cell sprouting. The distribution of Type IV collagen also supports its role as a signal for migration and tube formation for lymphatic endothelial cells.

scholarly journals Blue Light induces DNA‐damage in normal human skin keratinocytes

2021 ◽  
Author(s):  
Cécile Chamayou‐Robert ◽  
Carole DiGiorgio ◽  
Olivier Brack ◽  
Olivier Doucet
Keyword(s):  
Dna Damage ◽  
Human Skin ◽  
Blue Light ◽  
Normal Human Skin ◽  
Skin Keratinocytes ◽  
Normal Human

Telomerase regulation in normal human skin keratinocytes

1998 ◽  
Vol 16 ◽  
pp. S71
Author(s):  
V. Vormwald-Dogan ◽  
R. Figueroa ◽  
H. Lindenmaier ◽  
P. Boukamp
Keyword(s):  
Human Skin ◽  
Normal Human Skin ◽  
Skin Keratinocytes ◽  
Normal Human ◽  
Telomerase Regulation
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